Synthesis of Heroin from opium raw

[WillD]

Morphine extraction:
1. 1 kg Opium was dissolved in boiling water (750 ml).

2. It was added 250 g Ca(OH)2 and the heating removed.

3. The mixture was allowed to cool and stand overnight.
4. The solution was filtered, the residue dissolved in boiling water (250 ml) and re-filtered.
5. The combined filtrates were re-heated until the solution steamed, at this point the pH of the solution was adjusted to 8–9 with NH4Cl.

6. Left to stand overnight.
7. The solution was filtered to leave behind morphine base (65 g).

Morphine HCl:
1. Morphine base (65 g) was dissolved in 600 ml hot warm water.
2. 19 ml concentrated HCl and 25 g of charcoal were added.
3. The solution was warmed for 10 min and then filtered.
4. The filtrate was left to stand overnight.
5. Filtered to leave behind morphine hydrochloride (30 g).

Heroin base:
1. Acetic anhydride (80 g) was added slowly to morphine (30 g).

2. The resulting solution was heated and stirred at 85 *C for 2.25 h.
3. Allowed to cool to room temperature.
4. The solution was diluted with cold water (150 ml).
5. The solution was cooled on ice and made basic (pH 8– 10) with cold 10% sodium carbonate.

6. The resulting aqueous solution was extracted with chloroform (150 ml) and dried over MgSO4.
7. Evaporated to leave diacetylmorphine base (24 g).


Heroin HCl:
1. Diacetylmorphine base (from morphine hydrochloride) (24 g) was dissolved in acetone (150 ml).

2. Concentrated HCl was added at pH - 6.
3.The solution evaporated to leave behind diacetylmorphine hydrochloride (23 g).

 

[MadHatter]

How is this procedure different if acetyl chloride is used instead of acetic anhydride?

 

[WillD]

How is this procedure different if acetyl chloride is used instead of acetic anhydride?

DocXThis procedure is possible

 

[MadHatter]

This procedure is possible

William DampierYes, it's a known process. But I was wondering about the specifics, like reaction time and amounts. Can't find any info.

 

[WillD]

Yes, it's a known process. But I was wondering about the specifics, like reaction time and amounts. Can't find any info.

DocXThe conditions are the same

 

[None]

Is it possible to acetylate and synthesize morphine with acetic acid? With reflux

 

[None]

Morphine extraction:
1. 1 kg Opium was dissolved in boiling water (750 ml).
View attachment 1730
2. It was added 250 g Ca(OH)2 and the heating removed.
View attachment 1731
3. The mixture was allowed to cool and stand overnight.
4. The solution was filtered, the residue dissolved in boiling water (250 ml) and re-filtered.
5. The combined filtrates were re-heated until the solution steamed, at this point the pH of the solution was adjusted to 8–9 with NH4Cl.
View attachment 1732
6. Left to stand overnight.
7. The solution was filtered to leave behind morphine base (65 g).
View attachment 1733

Morphine HCl:
1. Morphine base (65 g) was dissolved in 600 ml hot warm water.
2. 19 ml concentrated HCl and 25 g of charcoal were added.
3. The solution was warmed for 10 min and then filtered.
4. The filtrate was left to stand overnight.
5. Filtered to leave behind morphine hydrochloride (30 g).
View attachment 1734

Heroin base:
1. Acetic anhydride (80 g) was added slowly to morphine (30 g).
View attachment 1735
2. The resulting solution was heated and stirred at 85 *C for 2.25 h.
3. Allowed to cool to room temperature.
4. The solution was diluted with cold water (150 ml).
5. The solution was cooled on ice and made basic (pH 8– 10) with cold 10% sodium carbonate.
View attachment 1736
6. The resulting aqueous solution was extracted with chloroform (150 ml) and dried over MgSO4.
7. Evaporated to leave diacetylmorphine base (24 g).


Heroin HCl:
1. Diacetylmorphine base (from morphine hydrochloride) (24 g) was dissolved in acetone (150 ml).
View attachment 1738
2. Concentrated HCl was added at pH - 6.
3.The solution evaporated to leave behind diacetylmorphine hydrochloride (23 gHi, before synthesizing with anhydrid

William Dampier

Morphine extraction:
1. 1 kg Opium was dissolved in boiling water (750 ml).
View attachment 1730
2. It was added 250 g Ca(OH)2 and the heating removed.
View attachment 1731
3. The mixture was allowed to cool and stand overnight.
4. The solution was filtered, the residue dissolved in boiling water (250 ml) and re-filtered.
5. The combined filtrates were re-heated until the solution steamed, at this point the pH of the solution was adjusted to 8–9 with NH4Cl.
View attachment 1732
6. Left to stand overnight.
7. The solution was filtered to leave behind morphine base (65 g).
View attachment 1733

Morphine HCl:
1. Morphine base (65 g) was dissolved in 600 ml hot warm water.
2. 19 ml concentrated HCl and 25 g of charcoal were added.
3. The solution was warmed for 10 min and then filtered.
4. The filtrate was left to stand overnight.
5. Filtered to leave behind morphine hydrochloride (30 g).
View attachment 1734

Heroin base:
1. Acetic anhydride (80 g) was added slowly to morphine (30 g).
View attachment 1735
2. The resulting solution was heated and stirred at 85 *C for 2.25 h.
3. Allowed to cool to room temperature.
4. The solution was diluted with cold water (150 ml).
5. The solution was cooled on ice and made basic (pH 8– 10) with cold 10% sodium carbonate.
View attachment 1736
6. The resulting aqueous solution was extracted with chloroform (150 ml) and dried over MgSO4.
7. Evaporated to leave diacetylmorphine base (24 g).


Heroin HCl:
1. Diacetylmorphine base (from morphine hydrochloride) (24 g) was dissolved in acetone (150 ml).
View attachment 1738
2. Concentrated HCl was added at pH - 6.
3.The solution evaporated to leave behind diacetylmorphine hydrochloride (23 g).
View attachment 1739

Morphine extraction:
1. 1 kg Opium was dissolved in boiling water (750 ml).
View attachment 1730
2. It was added 250 g Ca(OH)2 and the heating removed.
View attachment 1731
3. The mixture was allowed to cool and stand overnight.
4. The solution was filtered, the residue dissolved in boiling water (250 ml) and re-filtered.
5. The combined filtrates were re-heated until the solution steamed, at this point the pH of the solution was adjusted to 8–9 with NH4Cl.
View attachment 1732
6. Left to stand overnight.
7. The solution was filtered to leave behind morphine base (65 g).
View attachment 1733

Morphine HCl:
1. Morphine base (65 g) was dissolved in 600 ml hot warm water.
2. 19 ml concentrated HCl and 25 g of charcoal were added.
3. The solution was warmed for 10 min and then filtered.
4. The filtrate was left to stand overnight.
5. Filtered to leave behind morphine hydrochloride (30 g).
View attachment 1734

Heroin base:
1. Acetic anhydride (80 g) was added slowly to morphine (30 g).
View attachment 1735
2. The resulting solution was heated and stirred at 85 *C for 2.25 h.
3. Allowed to cool to room temperature.
4. The solution was diluted with cold water (150 ml).
5. The solution was cooled on ice and made basic (pH 8– 10) with cold 10% sodium carbonate.
View attachment 1736
6. The resulting aqueous solution was extracted with chloroform (150 ml) and dried over MgSO4.
7. Evaporated to leave diacetylmorphine base (24 g).


Heroin HCl:
1. Diacetylmorphine base (from morphine hydrochloride) (24 g) was dissolved in acetone (150 ml).
View attachment 1738
2. Concentrated HCl was added at pH - 6.
3.The solution evaporated to leave behind diacetylmorphine hydrochloride (23 g).
View attachment 1739

Hi, before synthesizing with anhydride, should we evaporate the hydrochloride solution or add anhydride to the same solution?

 

[None]

Hi, before synthesizing with anhydride, should we evaporate the hydrochloride solution or add anhydride to the same solution?

 

[Wallpaper]

Morphine extraction:
1. 1 kg Opium was dissolved in boiling water (750 ml).
View attachment 1730
2. It was added 250 g Ca(OH)2 and the heating removed.
View attachment 1731
3. The mixture was allowed to cool and stand overnight.
4. The solution was filtered, the residue dissolved in boiling water (250 ml) and re-filtered.
5. The combined filtrates were re-heated until the solution steamed, at this point the pH of the solution was adjusted to 8–9 with NH4Cl.
View attachment 1732
6. Left to stand overnight.
7. The solution was filtered to leave behind morphine base (65 g).
View attachment 1733

Morphine HCl:
1. Morphine base (65 g) was dissolved in 600 ml hot warm water.
2. 19 ml concentrated HCl and 25 g of charcoal were added.
3. The solution was warmed for 10 min and then filtered.
4. The filtrate was left to stand overnight.
5. Filtered to leave behind morphine hydrochloride (30 g).
View attachment 1734

Heroin base:
1. يضاف أنهيدريد الخل (80 جم) ببطء إلى المورفين (30 جم).
View attachment 1735
2. يسخن المحلول الناتج ويقلب عند 85 درجة مئوية لمدة 2.25 ساعة.
3. يسمح لتبرد لدرجة حرارة الغرفة.
4. تم تخفيف المحلول بالماء البارد (150 مل).
5. تم تبريد المحلول على الجليد وجعله قاعديًا (الأس الهيدروجيني 8-10) باستخدام كربونات الصوديوم 10٪ بارد.
View attachment 1736
6. تم استخلاص المحلول المائي الناتج باستخدام كلوروفورم (150 مل) وتجفيفه فوق MgSO4.
7. يتبخر ليترك قاعدة ثنائي الأسيتيل مورفين (24 جم).


الهيروين حمض الهيدروكلوريك:
1. تم إذابة قاعدة ثنائي الأسيتيل مورفين (من هيدروكلوريد المورفين) (24 جم) في الأسيتون (150 مل).
View attachment 1738
2. تمت إضافة حمض الهيدروكلوريك المركز عند الرقم الهيدروجيني - 6.
3- يتبخر المحلول ليترك وراءه ثنائي أسيتيل مورفين هيدروكلوريد (23 جم).
View attachment 1739

William Dampier

Morphine extraction:
1. 1 kg Opium was dissolved in boiling water (750 ml).
View attachment 1730
2. It was added 250 g Ca(OH)2 and the heating removed.
View attachment 1731
3. The mixture was allowed to cool and stand overnight.
4. The solution was filtered, the residue dissolved in boiling water (250 ml) and re-filtered.
5. The combined filtrates were re-heated until the solution steamed, at this point the pH of the solution was adjusted to 8–9 with NH4Cl.
View attachment 1732
6. Left to stand overnight.
7. The solution was filtered to leave behind morphine base (65 g).
View attachment 1733

Morphine HCl:
1. Morphine base (65 g) was dissolved in 600 ml hot warm water.
2. 19 ml concentrated HCl and 25 g of charcoal were added.
3. The solution was warmed for 10 min and then filtered.
4. The filtrate was left to stand overnight.
5. Filtered to leave behind morphine hydrochloride (30 g).
View attachment 1734

Heroin base:
1. Acetic anhydride (80 g) was added slowly to morphine (30 g).
View attachment 1735
2. The resulting solution was heated and stirred at 85 *C for 2.25 h.
3. Allowed to cool to room temperature.
4. The solution was diluted with cold water (150 ml).
5. The solution was cooled on ice and made basic (pH 8– 10) with cold 10% sodium carbonate.
View attachment 1736
6. The resulting aqueous solution was extracted with chloroform (150 ml) and dried over MgSO4.
7. Evaporated to leave diacetylmorphine base (24 g).


Heroin HCl:
1. Diacetylmorphine base (from morphine hydrochloride) (24 g) was dissolved in acetone (150 ml).
View attachment 1738
2. Concentrated HCl was added at pH - 6.
3.The solution evaporated to leave behind diacetylmorphine hydrochloride (23 g).
View attachment 1739

in the extraction of morphine
Point 5 is incomprehensible,can you explain more

 

[41Dxflatline]

in the extraction of morphine
Point 5 is incomprehensible,can you explain more

WallpaperAll the filtered liquid from step 4 is combined in one container then heated up until it starts to steam, then you keep adding ammonium chloride to the liquid until the ph reaches 8 or 9

 

[Midget_Impinger]

I wish I could get my hands on raw opium (or even morphine) to try this :-(

 

[cubesquare]

I wish I could get my hands on raw opium (or even morphine) to try this :-(

Midget_ImpingerYou can get raw opium from Nemesis market, a seller called Boomshankar has "artisanal opium" available.
It isn't cheap per gram, but it is the real deal.

http://nemesis555nchzn2dogee6mlc7xxgeeshqirmh3yzn4lo5cnd4s5a4yd.onion/r/7deefgpaap

(that's my market referral link, if you do buy, I get a minuscule kickback)

 

[cubesquare]

I wish I could get my hands on raw opium (or even morphine) to try this :-(

Midget_Impinger@Midget_Impinger @therealboomshankar has joined BreakingBad - maybe he could arrange some for you at a good first time offer?

 

[3l_p4t0_m4l3f1c0]

I wish I could get my hands on raw opium (or even morphine) to try this :-(

Midget_ImpingerI know some peoples with high quantity of raw spanish opium, it will be way cheaper than what you can find on usual markets, (around 10€ per gram or even cheaper). Let me know if you're interested. I would just be an intermediate, I have a little bit of this opium if you want to check what it's like.

 

[Dr.Mirakulix]

I know some peoples with high quantity of raw spanish opium, it will be way cheaper than what you can find on usual markets, (around 10€ per gram or even cheaper). Let me know if you're interested. I would just be an intermediate, I have a little bit of this opium if you want to check what it's like.

3l_p4t0_m4l3f1c0Hello, I'm very interested in the opium too. Could you pm me about it too, please? I d be very thankful!

 

[AS2005]

Hello

I had some questions about heroin, if possible, please answer

1. Is it possible to reduce the amount of morphine and add another substance instead?

2. What laboratory equipment is needed to make heroin?

3. Is there a movie about making heroin? If there is, please send it.

4. Explain steps 6 and 7 of the heroin base.

 

[pachemguy]

Working in producing base tonight

 

[Acidosis]

Working in producing base tonight

pachemguyPlease info of your job..keep in touch Dear.

 

[Acidosis]

Working in producing base tonight

pachemguyHi Dear...you finish the Production of H-base??all's nice ??

 

[Plinius]

I think there are a lot of problems in this process :
Example :
1 - they pass from from 65g of Morphine free base to 30g of Morphine HCl... Nobody would be so careless with a valued product... You just need to add hydrochloride acid at ambient temperature and controlled pH. Nobody will accept to loose more than 50% of a product like this.
2 - WHY using morphine hydrochloride to acetyl it in heroin, get heroin free base (???) and then pass again heroin base to hydrochloride ?? And what happens to the chlorine ions from morphine ??? They disappear ?
3 - Why they are drying the heroin product (and loosing weight) for add HCl later, assuming it is in solution, to make it evaporate finally ? (I mean, this drying on MgSO4 is not really necessarily at this point... But ok, quite common in chemistry, but not really useful here)

Honestly I have serious doubt on this process, especially about efficiency which is terrible.

 

[Plinius]

I think there are a lot of problems in this process :
Example :
1 - they pass from from 65g of Morphine free base to 30g of Morphine HCl... Nobody would be so careless with a valued product... You just need to add hydrochloride acid at ambient temperature and controlled pH. Nobody will accept to loose more than 50% of a product like this.
2 - WHY using morphine hydrochloride to acetyl it in heroin, get heroin free base (???) and then pass again heroin base to hydrochloride ?? And what happens to the chlorine ions from morphine ??? They disappear ?
3 - Why they are drying the heroin product (and loosing weight) for add HCl later, assuming it is in solution, to make it evaporate finally ? (I mean, this drying on MgSO4 is not really necessarily at this point... But ok, quite common in chemistry, but not really useful here)

Honestly I have serious doubt on this process, especially about efficiency which is terrible.

PliniusOk, the hydrochloride is neutralized later in the process, at the same time of acetic acid formed

 

[41Dxflatline]

The 65g of morphine base is extremely crude at this stage. They're not losing 35g of product.

 

[Plinius]

The 65g of morphine base is extremely crude at this stage. They're not losing 35g of product.

41DxflatlineMost of Papaver somniferum are know to content near 10% (or more in specialized fields) of morphine in dry opium.
Thus, even 65g is 6.5% which is awful, moreover the 3% of final hydrochloride is almost criminal haha !

 

[41Dxflatline]

Most of Papaver somniferum are know to content near 10% (or more in specialized fields) of morphine in dry opium.
Thus, even 65g is 6.5% which is awful, moreover the 3% of final hydrochloride is almost criminal haha !

PliniusIt's probably 20% detritus too and they never use dried.